Synonyms :

Vascular Endothelial Growth Factor121, VPF

Description :

VEGF is a potent growth and angiogenic cytokine. It stimulates proliferation and survival of endothelial cells, and promotes angiogenesis and vascular permeability. Expressed in vascularized tissues, VEGF plays a prominent role in normal and pathological angiogenesis. VEGF signals through three receptors; fms -like tyrosine kinase (flt-1), KDR gene product (the murine homolog of KDR is the flk-1 gene product) and the flt4 gene product. Due to its increased acidity, VEGF₁₂₁ circulates more freely than other VEGF forms, which bind more tightly with vascular heparin sulfates. Recombinant human VEGF₁₂₁ is a 28.4 kDa disulfide-linked homodimeric protein consisting of two 121 amino acid polypeptide chains.

Catalog #:

100-20A

Source :

E.coli

Purity :

Greater than 98% by SDS-PAGE gel and HPLC analyses.

Endotoxin Level :

Endotoxin level is less than 0.1 ng per ?g (1EU/?g).

Biological Activity :

Determined by the dose-dependent stimulation of the proliferation of human umbilical vein endothelial cells (HUVEC) using a concentration range of 0.2-0.4 ng/ml.

Selected References :

Selected List of References Citing This Product

AA Sequence :

PMAEGGGQNH HEVVKFMDVY QRSYCHPIET LVDIFQEYPD EIEYIFKPSC VPLMRCGGCC NDEGLECVPT EESNITMQIM RIKPHQGQHI GEMSFLQHNK CECRPKKDRA RQENCDKPRR

PubMed Link :

VEGF+AND+121

Country of Origin :

USA

Special Sizes: 
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Usage: 
For Research Use Only. Not for use in diagnostic or therapeutic procedures.